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Literature summary for 1.17.3.2 extracted from

  • Hayashi, K.; Kimata, H.; Obata, K.; Matsushita, A.; Fukata, A.; Hashimoto, K.; Noda, A.; Iwase, M.; Koike, Y.; Yokota, M.; Nagata, K.
    Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters (2008), J. Card. Fail., 14, 238-244.
    View publication on PubMed
Search for more literature for 1.17.3.2

Application

Application Comment Organism
pharmacology the enzyme is a target in treatment of heart failure Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
allopurinol treatment of TO-2 hamsters with allopurinol inhibits both the decrease in GSH/GSSG ratio and the increase in malondialdehyde levels in the heart Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Mesocricetus auratus xanthine oxidase inhibition, meaning a decrease in myocardial oxidative stress, improves left ventricular dysfunction in dilated cardiomyopathic hamsters, modelling, overview urate + H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
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 male TO-2 cardiomyopathic Syrian hamsters
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Mesocricetus auratus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2 production of superoxide radicals Mesocricetus auratus urate + H2O2
-
 ?
xanthine + H2O + O2 xanthine oxidase inhibition, meaning a decrease in myocardial oxidative stress, improves left ventricular dysfunction in dilated cardiomyopathic hamsters, modelling, overview Mesocricetus auratus urate + H2O2
-
 ?