Literature summary for 1.17.3.2 extracted from

Tamta, H.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies (2005), J. Enzyme Inhib. Med. Chem., 20, 317-324.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-(N-benzoylamino)purine	competitive, 50% inhibition at 0.00045 mM. Hydrogen bonding interaction involves N7 of the purine ring and N-H of R880, the N-H of the purine ring and OH of T1010	Bos taurus
8-bromoxanthine	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	commercial preparation	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000475	-	6-(N-benzoylamino)purine	25°C, pH 7.5	Bos taurus
0.4	-	8-bromoxanthine	25°C, pH 7.5	Bos taurus

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Release 2023.1 (January 2023)