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Literature summary for 1.17.1.9 extracted from
- Kinetic and chemical mechanisms of yeast formate dehydrogenase (1980), Biochemistry, 19, 3543-3550.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Br- | - |
Saccharomyces cerevisiae |  |
| Cl- | - |
Saccharomyces cerevisiae | |
| CN- | - |
Saccharomyces cerevisiae | |
| F- | - |
Saccharomyces cerevisiae | |
| HCO3- | - |
Saccharomyces cerevisiae | |
| N3- | - |
Saccharomyces cerevisiae | |
| NADH | - |
Saccharomyces cerevisiae | |
| NO2- | - |
Saccharomyces cerevisiae | |
| NO3- | - |
Saccharomyces cerevisiae | |
| OCN- | - |
Saccharomyces cerevisiae | |
| SCN- | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
NAD+ | - |
Saccharomyces cerevisiae | |
| 0.17 | - |
thio-NAD+ | - |
Saccharomyces cerevisiae | |
| 0.19 | - |
3-pyridinecarboxaldehyde-NAD+ | - |
Saccharomyces cerevisiae | |
| 0.54 | - |
deamino-NAD+ | - |
Saccharomyces cerevisiae | |
| 1.16 | - |
3-acetylpyridine-NAD+ | - |
Saccharomyces cerevisiae | |
| 1.7 | - |
formate | with NAD+ as electron acceptor | Saccharomyces cerevisiae | |
| 7.6 | - |
formate | with thio-NAD+ as electron acceptor | Saccharomyces cerevisiae | |
| 30 | - |
formate | with 3-pyridinecarboxaldehyde-NAD+ as electron acceptor | Saccharomyces cerevisiae | |
| 335 | - |
formate | with 3-acetylpyridine-NAD+ as electron acceptor | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| formate + NAD+ = CO2 + NADH + H+ | ordered kinetic mechanism with NAD+ adding before formate | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| formate + 3-acetylpyridine-NAD+ | - |
Saccharomyces cerevisiae | CO2 + 3-acetylpyridine-NADH | - |
r | |
| formate + 3-pyridinecarboxaldehyde-NAD+ | - |
Saccharomyces cerevisiae | CO2 + 3-pyridinecarboxaldehyde-NADH | - |
? | |
| formate + deamino-NAD+ | - |
Saccharomyces cerevisiae | CO2 + deamino-NADH | - |
r | |
| formate + NAD+ | - |
Saccharomyces cerevisiae | CO2 + NADH + H+ | - |
? | |
| formate + thio-NAD+ | - |
Saccharomyces cerevisiae | CO2 + thio-NADH | - |
r | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharomyces cerevisiae | |
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