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Literature summary for 1.17.1.8 extracted from
- Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate (1997), Biochemistry, 36, 15081-15088.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | design and evaluation of dihydropicolinate reductase inhibitors as broad spectrum antibiotics and herbicides | Escherichia coli |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| R-factor 21.4%, three-dimensional structure analysis , homotetramer with 3 molecules of NADH, 3 molecules of inhibitor 2,6-pyridinedicarboxylic acid, 1 phosphate ion and 186 water molecules per asymmetric unit in the model | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-pyridinedicarboxylic acid | - |
Escherichia coli |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 12000 | - |
- |
Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dihydrodipicolinate + NAD(P)H | Escherichia coli | lysine and diaminopimelate biosynthesis pathway | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P04036 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2,3-dihydrodipicolinate + NAD(P)H | - |
Escherichia coli | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
| 2,3-dihydrodipicolinate + NAD(P)H | lysine and diaminopimelate biosynthesis pathway | Escherichia coli | 2,3,4,5-tetrahydrodipicolinate + NAD(P)+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | homotetramer with identical subunits, each subunit with 2 domains, structure analysis | Escherichia coli |
| tetramer | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Escherichia coli | |
| NADPH | - |
Escherichia coli | |
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