Literature summary for 1.17.1.8 extracted from

Paiva, A.M.; Vanderwall, D.E.; Blanchard, J.S.; Kozarich, J.W.; Williamson, J.M.; Kelly, T.M.
Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis (2001), Biochim. Biophys. Acta, 1545, 67-77.

Search for more literature for 1.17.1.8

Application

Application	Comment	Organism
medicine	-	Escherichia coli
medicine	potential drug target in therapy of tuberculosis caused by resistent strains of Mycobacterium tuberculosis, molecular modeling for identification of potential inhibitors	Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment)	Organism
dapB gene, expression in Escherichia coli	Mycobacterium tuberculosis
dapB gene, overexpression from plasmid in Escherichia coli	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
2,6-pyridinedicarboxylic acid	-	Escherichia coli
2,6-pyridinedicarboxylic acid	-	Mycobacterium tuberculosis
additional information	investigation of inhibitory potential of diverse heterocyclic and aromatic compounds, overview	Mycobacterium tuberculosis
sulfonamide derivatives	-	Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2,3-dihydrodipicolinate + NAD(P)H	Escherichia coli	-	2,3,4,5-tetrahydrodipicolinate + NAD(P)+	-	?
2,3-dihydrodipicolinate + NAD(P)H	Mycobacterium tuberculosis	essentially involved in cell wall synthesis	2,3,4,5-tetrahydrodipicolinate + NAD(P)+	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P04036	-	-
Mycobacterium tuberculosis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
overexpression in Escherichia coli from plasmid	Escherichia coli
recombinant enzyme expressed in Escherichia coli	Mycobacterium tuberculosis

Reaction

Reaction	Comment	Organism	Reaction ID
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+	binding mechanism of diverse inhibitors	Mycobacterium tuberculosis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,3-dihydrodipicolinate + NAD(P)H	-	Mycobacterium tuberculosis	2,3,4,5-tetrahydrodipicolinate + NAD(P)+	-	?
2,3-dihydrodipicolinate + NAD(P)H	-	Escherichia coli	2,3,4,5-tetrahydrodipicolinate + NAD(P)+	-	?
2,3-dihydrodipicolinate + NAD(P)H	essentially involved in cell wall synthesis	Mycobacterium tuberculosis	2,3,4,5-tetrahydrodipicolinate + NAD(P)+	-	?

Synonyms

Synonyms	Comment	Organism
DHDP reductase	-	Mycobacterium tuberculosis

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Escherichia coli
NADPH	-	Mycobacterium tuberculosis
NADPH	-	Escherichia coli

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Release 2023.1 (January 2023)