Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | inhibition of enzyme activity in malignant and non-malignant mammary epithelial cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast tumor cell | - |
Homo sapiens | - |
mammary gland | constitutive expression and high activity of XDH in non-malignant cells | Homo sapiens | - |
MCF-7 cell | low XDH expression and activity | Homo sapiens | - |
MDA-MB-231 cell | low XDH expression and activity | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
XDH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | downregulation of enzyme expression in malignant and non-malignant mammary epithelial cells by 17beta-estradiol | down |
General Information | Comment | Organism |
---|---|---|
malfunction | the retinoic acid deficiency in breast tumour epithelial cells has been ascribed to an insufficient expression of either the enzyme(s) involved in its biosynthesis or the cellular retinol binding protein or both, overview | Homo sapiens |