Literature summary for 1.17.1.4 extracted from

Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Hori, H.; Matsumura, T.; Eger, B.T.; Pai, E.F.
Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant (2005), J. Biol. Chem., 280, 24888-24894.

Search for more literature for 1.17.1.4

Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant C535A/C992R/C1324S	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
C535A	resistant to conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine	Rattus norvegicus
C535A/C992R	slow conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine, conversion is blocked by NADH	Rattus norvegicus
C535A/C992R/C1316S	completely resistant to conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine	Rattus norvegicus
C535A/C992R/C1324S	completely resistant to conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine	Rattus norvegicus
C992R	resistant to conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	conversion from dehydrogenase to oxidase by incubation with 4,4-dithiodipyridine	Rattus norvegicus

Reaction

Reaction	Comment	Organism	Reaction ID
xanthine + NAD+ + H2O = urate + NADH + H+	mechanism of conversion of dehydrogenase form to oxidase form	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)