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Literature summary for 1.17.1.4 extracted from

  • Hughes, R.K.; Doyle, W.A.; Chovnick, A.; Whittle, J.R.S.; Burke, J.F.; Bray, R.C.
    Use of rosy mutant strains of Drosophila melanogaster to probe the structure and function of xanthine dehydrogenase (1992), Biochem. J., 285, 507-513.
No PubMed abstract available

Application

Application Comment Organism
analysis use of rosy mutant strains to probe structure and function of xanthine dehydrogenase Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Fe iron-sulfur groups Drosophila melanogaster
Iron-sulfur-center substitutions G42E, E89K, L127F located within the iron-sulfur domain Drosophila melanogaster
Mo
-
Drosophila melanogaster
molybdenum-center substitutions G800E, G1011E, G1164R, G1266D, S1275F located within the pterin molybdenum cofactor domain Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-pterin + NAD+ + H2O Drosophila melanogaster i.e. pterin isoxanthopterin + NADH
-
?
xanthine + NAD+ + H2O Drosophila melanogaster
-
urate + NADH
-
?
xanthine + O2 + H2O Drosophila melanogaster
-
urate + O2- + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
whole body selection of 11 rosy mutant strain, corresponding to single amino acid substitutions for detailed studies on the activities Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-pterin + NAD+ + H2O i.e. pterin Drosophila melanogaster isoxanthopterin + NADH
-
?
2-amino-4-hydroxypterin + NAD+ + H2O i.e. pterin Drosophila melanogaster isoxanthopterin + NADH
-
?
NADH + electron acceptor + H2O electron acceptors: 2,6-dichlorphenolindophenol or methyl viologen Drosophila melanogaster NAD+ + reduced electron acceptor
-
?
NADPH + phenazine methosulfate + cytochrome c
-
Drosophila melanogaster NADP+ + ?
-
?
xanthine + 2,6-dichlorophenolindophenol + H2O
-
Drosophila melanogaster urate + ?
-
?
xanthine + NAD+ + H2O
-
Drosophila melanogaster urate + NADH
-
?
xanthine + O2 + H2O
-
Drosophila melanogaster urate + O2- + 2 H+
-
?
xanthine + phenazine methosulfate + cytochrome c + H2O
-
Drosophila melanogaster urate + ?
-
?

Cofactor

Cofactor Comment Organism Structure
FAD substitutions G348E, G353D, S357F located within the flavin/NAD+/NADH-domain Drosophila melanogaster
additional information
-
Drosophila melanogaster
NAD+
-
Drosophila melanogaster