Literature summary for 1.16.3.2 extracted from

Honarmand Ebrahimi, K.; Bill, E.; Hagedoorn, P.L.; Hagen, W.R.
The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement (2012), Nat. Chem. Biol., 8, 941-948.

Search for more literature for 1.16.3.2

Protein Variants

Protein Variants	Comment	Organism
E129C	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus
E129Q	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus
E129R	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus
E130H	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus
E17H	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus
E50H	the mutant shows severely reduced iron oxidation rate compared to the wild type enzyme	Pyrococcus furiosus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	the enzyme has three Fe2+ binding events per subunit	Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Fe(II) + O2 + H2O	Pyrococcus furiosus	-	[FeO(OH)] + H+ + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus furiosus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Fe(II) + O2 + H2O	-	Pyrococcus furiosus	[FeO(OH)] + H+ + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
Ftn	-	Pyrococcus furiosus

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Release 2023.1 (January 2023)