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Literature summary for 1.16.3.2 extracted from

  • Bou-Abdallah, F.; Yang, H.; Awomolo, A.; Cooper, B.; Woodhall, M.; Andrews, S.; Chasteen, N.
    Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA) (2014), Biochemistry, 53, 483-495.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.16.3.2

Protein Variants

Protein Variants Comment Organism
E126A the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein Escherichia coli
E130A the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein Escherichia coli
E17A the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme Escherichia coli
E49A the mutation causes a decrease in the Fe2+/O2 stoichiometry from about 3 to about 2 for the first 48 Fe2+ added to the protein Escherichia coli
E94A the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme Escherichia coli
H53A the mutation increases the Fe2+/O2 stoichiometry from about 3 to about 4 compared to the wild type enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fe(II) + H2O2 + H2O Escherichia coli
-
 [FeO(OH)] + H+
-
 ?
Fe(II) + O2 + H2O Escherichia coli
-
 [FeO(OH)] + H+ + H2O2
-
 ?
Fe(II) + O2 + H2O Escherichia coli overall reaction [FeO(OH)] + H+ + H2O2
-
 ?
additional information Escherichia coli although H2O2 is a product of dioxygen reduction in FtnA and oxidation occurs with a stoichiometry of Fe2+/O2 about 3:1 most of the H2O2 produced is consumed in subsequent reactions with a 2:1 Fe2+/H2O2 stoichiometry, thus suppressing hydroxyl-radical formation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fe(II) + H2O2 + H2O
-
 Escherichia coli [FeO(OH)] + H+
-
 ?
Fe(II) + O2 + H2O
-
 Escherichia coli [FeO(OH)] + H+ + H2O2
-
 ?
Fe(II) + O2 + H2O overall reaction Escherichia coli [FeO(OH)] + H+ + H2O2
-
 ?
additional information although H2O2 is a product of dioxygen reduction in FtnA and oxidation occurs with a stoichiometry of Fe2+/O2 about 3:1 most of the H2O2 produced is consumed in subsequent reactions with a 2:1 Fe2+/H2O2 stoichiometry, thus suppressing hydroxyl-radical formation Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
FtnA
-
 Escherichia coli
nonheme bacterial ferritin
-
 Escherichia coli