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Literature summary for 1.16.3.1 extracted from

  • Stoj, C.; Kosman, D.J.
    Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin implication for function (2003), FEBS Lett., 554, 422-426 .
    View publication on PubMed
Search for more literature for 1.16.3.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0054
-
 Fe(II) pH 5.0, temperature not specified in the publication Saccharomyces cerevisiae
0.0083
-
 Fe(II) pH 5.0, temperature not specified in the publication Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu+ multicopper oxidase Homo sapiens
Cu+ multicopper oxidase Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 Fe(II) + 4 H+ + O2 Homo sapiens the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 Saccharomyces cerevisiae the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 Saccharomyces cerevisiae ATCC 204508 the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance 4 Fe(III) + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00450
-
-
Saccharomyces cerevisiae P38993
-
-
Saccharomyces cerevisiae ATCC 204508 P38993
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 Fe(II) + 4 H+ + O2 the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance Homo sapiens 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance Saccharomyces cerevisiae 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 similar kinetic activity towards Cu+ as substrate Homo sapiens 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 similar kinetic activity towards Cu+ as substrate. The ferroxidase and cuprous oxidase activities are due to the same electron transfer site on the enzyme Saccharomyces cerevisiae 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance Saccharomyces cerevisiae ATCC 204508 4 Fe(III) + 2 H2O
-
 ?
4 Fe(II) + 4 H+ + O2 similar kinetic activity towards Cu+ as substrate. The ferroxidase and cuprous oxidase activities are due to the same electron transfer site on the enzyme Saccharomyces cerevisiae ATCC 204508 4 Fe(III) + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
ceruloplasmin
-
 Homo sapiens
fet3p
-
 Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.505
-
 Fe(II) pH 5.0, temperature not specified in the publication Homo sapiens
1.07
-
 Fe(II) pH 5.0, temperature not specified in the publication Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance Homo sapiens
physiological function the enzyme is required for iron homeostasis. It also plays a major role in maintaining the cuprous/cupric redox balance Saccharomyces cerevisiae