Literature summary for 1.16.3.1 extracted from

Martin, F.; Linden, T.; Katschinski, D.M.; Oehme, F.; Flamme, I.; Mukhopadhyay, C.K.; Eckhardt, K.; Troeger, J.; Barth, S.; Camenisch, G.; Wenger, R.H.
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation (2005), Blood, 105, 4613-4619.

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Activating Compound

Activating Compound	Comment	Organism	Structure
CuCl2	increase in enzyme mRNA due to transcriptional activation of enzyme genes promoter	Mus musculus

Application

Application	Comment	Organism
medicine	both hypoxia and CuCl2 increase ceruloplasmin mRNA levels in hepatoma cells due to transcriptional induction of enzyme gene promoter	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	hypoxic mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	both hypoxia and CuCl2 increase ceruloplasmin mRNA levels in hepatoma cells due to transcriptional induction of enzyme gene promoter	Mus musculus	-

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Release 2023.1 (January 2023)