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Literature summary for 1.16.1.10 extracted from

  • Tian, Q.; Zhang, X.; Yang, A.; Wang, T.; Zhang, W.H.
    CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity (2016), Plant Sci., 46, 70-79 .
    View publication on PubMed
Search for more literature for 1.16.1.10

Activating Compound

Activating Compound Comment Organism Structure
CIPK23 a protein kinase, required for enzyme activity because CIPK23 helps in iron aquisition. Involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
gene FRO2, quantitative real-time PCR isozyme expression analysis Arabidopsis thaliana
gene FRO3, quantitative real-time PCR isozyme expression analysis Arabidopsis thaliana
gene FRO5, quantitative real-time PCR isozyme expression analysis Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 Fe(II)-siderophore + NAD(P)+ + H+ Arabidopsis thaliana
-
 2 Fe(III)-siderophore + NAD(P)H
-
 ?
2 Fe(II)-siderophore + NAD(P)+ + H+ Arabidopsis thaliana Col-0
-
 2 Fe(III)-siderophore + NAD(P)H
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana F4I4K7
-
-
Arabidopsis thaliana P92949
-
-
Arabidopsis thaliana Q9FLW2
-
-
Arabidopsis thaliana Col-0 F4I4K7
-
-
Arabidopsis thaliana Col-0 P92949
-
-
Arabidopsis thaliana Col-0 Q9FLW2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 Fe(II)-ferrozine + NAD(P)+ + H+
-
 Arabidopsis thaliana 2 Fe(III)-ferrozine + NAD(P)H
-
 ?
2 Fe(II)-ferrozine + NAD(P)+ + H+
-
 Arabidopsis thaliana Col-0 2 Fe(III)-ferrozine + NAD(P)H
-
 ?
2 Fe(II)-siderophore + NAD(P)+ + H+
-
 Arabidopsis thaliana 2 Fe(III)-siderophore + NAD(P)H
-
 ?
2 Fe(II)-siderophore + NAD(P)+ + H+
-
 Arabidopsis thaliana Col-0 2 Fe(III)-siderophore + NAD(P)H
-
 ?

Synonyms

Synonyms Comment Organism
FCR
-
 Arabidopsis thaliana
ferric chelate reductase
-
 Arabidopsis thaliana
FRO protein
-
 Arabidopsis thaliana
FRO2
-
 Arabidopsis thaliana
FRO3
-
 Arabidopsis thaliana
FRO5
-
 Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 assay at Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Arabidopsis thaliana
NADPH
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity down

General Information

General Information Comment Organism
malfunction lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity, leading to chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions, phenotype, overview Arabidopsis thaliana
metabolism the protein kinase CIPK23 is involved in iron acquisition. Lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by downregulating ferric chelate reductase activity. Iron deficiency evokes an increase in cytosolic Ca2+ concentration, and the elevated Ca2+ binds to CBL1/CBL9, leading to activation of CIPK23, CBL-CIPK23complexes might be as nutritional sensors to sense and regulate the mineral homeostasis in Arabisopsis thaliana. Regulation of FCR activity by CIPK23 may not be achieved by modulation of genes FRO2, FRO3 and FRO5 at transcriptional level Arabidopsis thaliana
physiological function FCR activity in plants not only depends on FRO expression, abundance of FRO proteins, and but also depends on the levels of heme, ATP and NADPH/NADH Arabidopsis thaliana