Cloned (Comment) | Organism |
---|---|
recombinant expression in HEK293 cell plasma membrane | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockout in neurons expressing FRRS1L sgRNAs | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | enzyme localization study, overview | Mus musculus | - |
- |
plasma membrane | - |
Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | B1AXV0 | - |
- |
Mus musculus C57B6 | B1AXV0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | FRRS1L is a component of native AMPAR complexes in the brain | Mus musculus | - |
hippocampus | native FRRS1L in hippocampus is localized at dynein, but not kinesin5B, vesicles | Mus musculus | - |
additional information | enzyme localization study, overview | Mus musculus | - |
neuron | hippocampal primary neuron cultures | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Ferric chelate reductase 1 like protein | - |
Mus musculus |
FRRS1L | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | ferric chelate reductase 1 like protein (FRRS1L) mutations in human lead to epilepsy, choreoathetosis, and cognitive deficits. Overexpression of enzyme FRRS1L in hippocampal neurons does not change glutamatergic synaptic transmission, but single-cell knockout of FRRS1L strongly reduces the surface and total expression levels of GluA1 in cultured hippocampal neurons, and significantly decreases AMPAR-mediated synaptic transmission in mouse hippocampal pyramidal neurons | Mus musculus |
physiological function | recombinant FRRS1L interacts with both GluA1 and GluA2 subunits of AMPA receptors, AMPARs, but does not form dimers/oligomers, in HEK293 cells. Important role of FRRS1L in the regulation of excitatory synaptic strength. FRRS1L is a component of native AMPAR complexes in the brain | Mus musculus |