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Literature summary for 1.16.1.10 extracted from

  • Han, W.; Wang, H.; Li, J.; Zhang, S.; Lu, W.
    Ferric chelate reductase 1 like protein (FRRS1L) associates with dynein vesicles and regulates glutamatergic synaptic transmission (2017), Front. Mol. Neurosci., 10, 402 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in HEK293 cell plasma membrane Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout in neurons expressing FRRS1L sgRNAs Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information enzyme localization study, overview Mus musculus
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plasma membrane
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Mus musculus 5886
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Organism

Organism UniProt Comment Textmining
Mus musculus B1AXV0
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Mus musculus C57B6 B1AXV0
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Source Tissue

Source Tissue Comment Organism Textmining
brain FRRS1L is a component of native AMPAR complexes in the brain Mus musculus
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hippocampus native FRRS1L in hippocampus is localized at dynein, but not kinesin5B, vesicles Mus musculus
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additional information enzyme localization study, overview Mus musculus
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neuron hippocampal primary neuron cultures Mus musculus
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Synonyms

Synonyms Comment Organism
Ferric chelate reductase 1 like protein
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Mus musculus
FRRS1L
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Mus musculus

General Information

General Information Comment Organism
malfunction ferric chelate reductase 1 like protein (FRRS1L) mutations in human lead to epilepsy, choreoathetosis, and cognitive deficits. Overexpression of enzyme FRRS1L in hippocampal neurons does not change glutamatergic synaptic transmission, but single-cell knockout of FRRS1L strongly reduces the surface and total expression levels of GluA1 in cultured hippocampal neurons, and significantly decreases AMPAR-mediated synaptic transmission in mouse hippocampal pyramidal neurons Mus musculus
physiological function recombinant FRRS1L interacts with both GluA1 and GluA2 subunits of AMPA receptors, AMPARs, but does not form dimers/oligomers, in HEK293 cells. Important role of FRRS1L in the regulation of excitatory synaptic strength. FRRS1L is a component of native AMPAR complexes in the brain Mus musculus