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Literature summary for 1.15.1.1 extracted from

  • Gu, W.; Chen, J.; Hou, L.; Huang, Y.; Xia, S.; Meng, Q.; Wang, W.
    The superoxide dismutase from red claw crayfish, Cherax quadricarinatus molecular cloning and characterization analysis (2014), Zool. Sci., 31, 725-734 .
    View publication on PubMed
Search for more literature for 1.15.1.1

Cloned(Commentary)

Cloned (Comment) Organism
gene SOD, and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Cherax quadricarinatus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Cherax quadricarinatus
-
-
mitochondrion the enzyme sequence encodes 218 amino acids with a 20 amino acid mitochondrial targeting sequence in the N-terminus Cherax quadricarinatus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a CuZnSOD, Cherax quadricarinatus ecCuZnSOD contains a Cu signature from 59 to 69 (GFHVHEKGDLG), and four Cu binding sites (His 61,63, 78, and 137) Cherax quadricarinatus
Mn2+ a MnSOD, Cherax quadricarinatus mtMnSOD contains a manganese superoxide dismutase domain (DVWEHAYY) from 180-187, and four conserved amino acids responsible for binding manganese (His48, His96, Asp180, and His184) Cherax quadricarinatus
Zn2+ a CuZnSOD, Cherax quadricarinatus ecCuZnSOD contains a Zn signature from 155 to 166 (GNAGQRSGCGII) and four Zn binding sites (His 78, 86, and 95, and Asp 98) Cherax quadricarinatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 superoxide + 2 H+ Cherax quadricarinatus
-
 O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Cherax quadricarinatus I3VPJ9
-
-
Cherax quadricarinatus I3VPK0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gill
-
 Cherax quadricarinatus
-
heart
-
 Cherax quadricarinatus
-
hemocyte
-
 Cherax quadricarinatus
-
hepatopancreas
-
 Cherax quadricarinatus
-
intestine
-
 Cherax quadricarinatus
-
additional information enzyme expression pattern, overview Cherax quadricarinatus
-
muscle
-
 Cherax quadricarinatus
-
nerve very low expression level Cherax quadricarinatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 superoxide + 2 H+
-
 Cherax quadricarinatus O2 + H2O2
-
 ?

Subunits

Subunits Comment Organism
? x * 24000, about, sequence calculation Cherax quadricarinatus

Synonyms

Synonyms Comment Organism
ecCuZnSOD
-
 Cherax quadricarinatus
extracellular copper-zinc superoxide dismutase
-
 Cherax quadricarinatus
mitochondrial manganese superoxide dismutase
-
 Cherax quadricarinatus
mtMnSOD
-
 Cherax quadricarinatus
SOD
-
 Cherax quadricarinatus

pI Value

Organism Comment pI Value Maximum pI Value
Cherax quadricarinatus sequence calculation
-
 8.77

Expression

Organism Comment Expression
Cherax quadricarinatus mtMnSOD in hepatopancreas is upregulated after Aeromonas hydrophila inoculation, whereas it is downregulated after Spiroplasma eriocheiris challenge, enzyme expression pattern, overview down
Cherax quadricarinatus mRNA transcription of enzyme ecCuZnSOD in hemocytes and gill is upregulated after inoculation with Spiroplasma eriocheiris and Aeromonas hydrophila. mtMnSOD in hepatopancreas is upregulated after Aeromonas hydrophila inoculation, whereas it is downregulated after Spiroplasma eriocheiris challenge, enzyme expression pattern, overview up
Cherax quadricarinatus mRNA transcription of enzyme ecCuZnSOD in the hepatopancreas, hemocytes, and gill is upregulated after inoculation with Spiroplasma eriocheiris and Aeromonas hydrophila, enzyme expression pattern, overview up

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in protecting some tissues from reactive oxygen intermediates produced during challenge from Spiroplasma eriocheiris and Aeromonas hydrophila Cherax quadricarinatus