Protein Variants | Comment | Organism |
---|---|---|
G93A | naturally occuring mutation, mutant SOD1-induced cytotoxicity protection | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(((2,4-dichlorobenzyl)(propyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 630 nM | Homo sapiens | |
5-(((2,4-dichlorobenzyl)(propyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 630 nM | Mus musculus | |
5-(((3,5-dichlorobenzyl)(ethyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 420 nM | Homo sapiens | |
5-(((3,5-dichlorobenzyl)(ethyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 420 nM | Mus musculus | |
5-(((3,5-dichlorobenzyl)(isopropyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00108 mM | Homo sapiens | |
5-(((3,5-dichlorobenzyl)(isopropyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00108 mM | Mus musculus | |
5-(((3,5-dichlorobenzyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 480 nM | Homo sapiens | |
5-(((3,5-dichlorobenzyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 480 nM | Mus musculus | |
5-(((3,5-dichlorobenzyl)(propyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 470 nM | Homo sapiens | |
5-(((3,5-dichlorobenzyl)(propyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 470 nM | Mus musculus | |
5-(((3,5-dichlorophenethyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00164 mM | Homo sapiens | |
5-(((3,5-dichlorophenethyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00164 mM | Mus musculus | |
5-(((3-(3,5-dichlorophenyl)propyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00332 mM | Homo sapiens | |
5-(((3-(3,5-dichlorophenyl)propyl)(methyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00332 mM | Mus musculus | |
5-((benzyl(3,5-dichlorobenzyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00245 mM | Homo sapiens | |
5-((benzyl(3,5-dichlorobenzyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00245 mM | Mus musculus | |
5-((cyclopropyl(3,5-dichlorobenzyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00134 mM | Homo sapiens | |
5-((cyclopropyl(3,5-dichlorobenzyl)amino)methyl)-1H-pyrazol-3(2H)-one | EC50 value is 0.00134 mM | Mus musculus | |
5-[(3,5-dichlorophenoxy)methyl]-1,2-dihydro-3H-pyrazol-3-one | EC50 value is 400 nM | Homo sapiens | |
5-[(3,5-dichlorophenoxy)methyl]-1,2-dihydro-3H-pyrazol-3-one | EC50 value is 400 nM | Mus musculus | |
5-[[(3,5-dichlorophenyl)(methyl)amino]methyl]-1,2-dihydro-3H-pyrazol-3-one | EC50 value is 570 nM | Homo sapiens | |
5-[[(3,5-dichlorophenyl)(methyl)amino]methyl]-1,2-dihydro-3H-pyrazol-3-one | EC50 value is 570 nM | Mus musculus | |
di-N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium sulfate | EC50 value is 480 nM | Homo sapiens | |
di-N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium sulfate | EC50 value is 480 nM | Mus musculus | |
additional information | pyrazolone derivatives are inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation and are useful as drugs in treatment of amyotrophic lateral sclerosis (ALS). Design and synthesis of a series of tertiary amine-containing pyrazolones and their structure-activity relationships, conjugate salts greatly improved their solubility, overview | Homo sapiens | |
additional information | pyrazolone derivatives are inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation and toxicity, and are useful as drugs in treatment of amyotrophic lateral sclerosis (ALS). Design and synthesis of a series of tertiary amine-containing pyrazolones and their structure-activity relationships, conjugate salts greatly improve their solubility, overview. Identification of several neuron-protection scaffolds based on mitigating protein aggregation and toxicity. A tertiary amine fragment is incorporated into the linker between the pyrazolone and the aryl group on the basis of principles of optimal brain exposure in CNS drug molecule design, the tertiary amine pyrazolone scaffolds exhibited superior properties for potential neuronal activity and in metabolic studies, such as microsomal stability, plasma stability, and Caco-2 permeability | Mus musculus | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium chloride | EC50 value is 510 nM | Homo sapiens | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium chloride | EC50 value is 510 nM | Mus musculus | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium citrate | EC50 value is 480 nM | Homo sapiens | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium citrate | EC50 value is 480 nM | Mus musculus | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium dibasic phosphate | EC50 value is 480 nM | Homo sapiens | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium dibasic phosphate | EC50 value is 480 nM | Mus musculus | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium L-tartrate | EC50 value is 480 nM | Homo sapiens | |
N-(3,5-dichlorobenzyl)-N-methyl-1-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)methanaminium L-tartrate | EC50 value is 480 nM | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 superoxide + 2 H+ | Mus musculus | - |
O2 + H2O2 | - |
? | |
2 superoxide + 2 H+ | Homo sapiens | - |
O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
Caco-2 cell | - |
Homo sapiens | - |
central nervous system | - |
Mus musculus | - |
central nervous system | - |
Homo sapiens | - |
spinal cord | - |
Mus musculus | - |
spinal cord | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 superoxide + 2 H+ | - |
Mus musculus | O2 + H2O2 | - |
? | |
2 superoxide + 2 H+ | - |
Homo sapiens | O2 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SOD1 | - |
Mus musculus |
SOD1 | - |
Homo sapiens |
superoxide dismutase 1 | - |
Mus musculus |
superoxide dismutase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | pyrazolone derivatives are inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation | Mus musculus |