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Literature summary for 1.15.1.1 extracted from

  • Inarrea, P.; Casanova, A.; Alava, M.A.; Iturralde, M.; Cadenas, E.
    Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450 (2011), Free Radic. Biol. Med., 50, 1575-1581.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.15.1.1

Activating Compound

Activating Compound Comment Organism Structure
dihydrotestosterone
-
 Rattus norvegicus
estradiol
-
 Rattus norvegicus
Melatonin
-
 Rattus norvegicus
additional information activation of intermembrane space SOD1 upon oxidation of critical thiols. Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole Rattus norvegicus
testosterone
-
 Rattus norvegicus
vitamin D
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
amiodarone
-
 Rattus norvegicus
amitriptyline
-
 Rattus norvegicus
ketoconazole
-
 Rattus norvegicus
Mg2+
-
 Rattus norvegicus
additional information melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole, and by tiron, a superoxide radical specific scavenger Rattus norvegicus
Omeprazole
-
 Rattus norvegicus
Tiron
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial intermembrane space
-
 Rattus norvegicus 5758
-
additional information subcellular localization study of SOD1, overview Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a CuZn-superoxide dismutase Rattus norvegicus
Zn2+ a CuZn-superoxide dismutase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male rats
-
Rattus norvegicus Wistar
-
 male rats
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from mitochondrial intermembrane space of livber microsomes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
Cu,Zn-superoxide dismutase
-
 Rattus norvegicus
SOD1
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function expression and activity of the mitochondrial P450 system along with substrate availability may contribute to mitochondrial function regulation via activation of IMS SOD1. Activation of intermembrane space SOD1 after incubation of rat liver intact mitochondria with P450 substrates significantly prevents the loss of aconitase activity in the mitochondrial matrix, general mechanism for the SOD1 activation mediated by P450 enzymes, overview Rattus norvegicus