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Literature summary for 1.15.1.1 extracted from

  • Gao, F.; Koenitzer, J.R.; Tobolewski, J.M.; Jiang, D.; Liang, J.; Noble, P.W.; Oury, T.D.
    Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan (2008), J. Biol. Chem., 283, 6058-6066.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.15.1.1

Protein Variants

Protein Variants Comment Organism
additional information hyaluronan levels are increased in the bronchoalveolar lavage fluid after asbestos-induced pulmonary injury, and this response is markedly enhanced in EC-SOD knock-out mice, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis ?
-
 ?
O2.- + H+ Homo sapiens EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview O2 + H2O2
-
 ?
O2.- + H+ Mus musculus EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments O2 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male C57BL/6 mice
-

Purification (Commentary)

Purification (Comment) Organism
EC-SOD from aorta Homo sapiens
native EC-SOD from mouse lungs by hyaluronic acid affinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
lung high expression level of EC-SOD Mus musculus
-
lung high expression level of EC-SOD Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information EC-SOD protects the lung in both bleomycin- and asbestos-induced models of pulmonary fibrosis Homo sapiens ?
-
 ?
O2.- + H+
-
 Mus musculus O2 + H2O2
-
 ?
O2.- + H+
-
 Homo sapiens O2 + H2O2
-
 ?
O2.- + H+ EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments, thereby preventing activation of polymorphic neutrophil chemotaxis by fragmented hyaluronic acid, overview Homo sapiens O2 + H2O2
-
 ?
O2.- + H+ EC-SOD plays an important role in regulating inflammatory responses to pulmonary injury, EC-SOD binds directly to hyaluronic acid via its matrix-binding domain and may inhibit pulmonary inflammation in part by preventing superoxide-mediated fragmentation of hyaluronan to low molecular mass fragments Mus musculus O2 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
EC-SOD
-
 Mus musculus
EC-SOD
-
 Homo sapiens
extracellular superoxide dismutase
-
 Mus musculus
extracellular superoxide dismutase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens