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Literature summary for 1.14.99.66 extracted from

  • Brasacchio, D.; Okabe, J.; Tikellis, C.; Balcerczyk, A.; George, P.; Baker, E.K.; Calkin, A.C.; Brownlee, M.; Cooper, M.E.; El-Osta, A.
    Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail (2009), Diabetes, 58, 1229-1236 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus C57BL/6
-
[histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2 Homo sapiens
-
[histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
-
[histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60341
-
-
Mus musculus Q6ZQ88 male apolipoprotein knockout (apoE KO) mice
-
Mus musculus C57BL/6 Q6ZQ88 male apolipoprotein knockout (apoE KO) mice
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme catalyzes the demethylation of H3K9me2/me1 (EC 1.14.11.65) and H3K4me2/me1 Homo sapiens ?
-
?
additional information the bifunctional enzyme catalyzes the demethylation of H3K9me2/me1 (EC 1.14.11.65) and H3K4me2/me1 Mus musculus ?
-
?
additional information the bifunctional enzyme catalyzes the demethylation of H3K9me2/me1 (EC 1.14.11.65) and H3K4me2/me1 Mus musculus C57BL/6 ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
Mus musculus C57BL/6 [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
LSD1
-
Homo sapiens
LSD1
-
Mus musculus
More see also for EC 1.14.11.65 Homo sapiens
More see also for EC 1.14.11.65 Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FAD
-
Mus musculus

General Information

General Information Comment Organism
additional information transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters Homo sapiens
additional information transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters Mus musculus
physiological function LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active methylation mark. LSD1 is associated with co-repressor complexes and promotes suppression or activation of gene expression, e.g. LSD1 might be associated to cooperative recruitment to the NFkappaB p65 site for activation in hyperglycemia Homo sapiens
physiological function LSD1 is a nuclear amine oxidase that utilizes oxygen as an electron acceptor to reduce methylated lysine to form lysine. It demethylates H3K4m1 and H3K4m2, as well as H3K9m1 and H3K9m2 as a removal of the active methylation mark. LSD1 is associated with co-repressor complexes and promotes suppression or activation of gene expression, e.g. LSD1 might be associated to cooperative recruitment to the NFkappaB p65 site for activation in hyperglycemia Mus musculus