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Literature summary for 1.14.99.66 extracted from

  • Vyas, R.N.; Meredith, D.; Lane, R.P.
    Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line (2017), Mol. Cell. Neurosci., 82, 1-11 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information RNAi knockdown of LSD1 expression leads to undetectable levels in about 90% of olfactory-placode-derived cell line (OP-6) cells in culture, modeling. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
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[histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2 Mus musculus
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[histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6ZQ88
-
-

Source Tissue

Source Tissue Comment Organism Textmining
olfactory receptor neuron olfactory-placode-derived cell line, OP-6 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme catalyzes the demethylation of H3K4me2/me1 and H3K9me2/me1 (EC 1.14.11.65) Mus musculus ?
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-N6-methyl-L-lysine 4 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6-methyl-L-lysine 4 + 2-oxoglutarate + O2
-
Mus musculus [histone H3]-L-lysine 4 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
KDM1A
-
Mus musculus
LSD1
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Mus musculus
lysine-specific demethylase-1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
FAD dependent on Mus musculus

General Information

General Information Comment Organism
malfunction depletion of LSD1 in an immortalized olfactory-placode-derived cell line (OP6) results in multigenic and multiallelic odorant receptor (OR) transcription per cell, while not seemingly disrupting the ability of these cells to activate new OR genes during clonal expansion. LSD1 depletion does not seem to alter OR representation in OP6 cell populations. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations Mus musculus
physiological function function of the mammalian olfactory system depends on specialized olfactory sensory neurons (OSNs) that each express only one allele of one odorant receptor (OR) gene (monogenic). The lysine-specific demethylase-1 (LSD1) has a role in silencing additional OR alleles in the immortalized olfactory-placode-derived cell line (OP6) cellular context. LSD1 protein removes activating H3K4 or silencing H3K9 methylation marks in a variety of developmental contexts Mus musculus