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Literature summary for 1.14.99.66 extracted from

  • Magerl, C.; Ellinger, J.; Braunschweig, T.; Kremmer, E.; Koch, L.K.; Hoeller, T.; Buettner, R.; Luescher, B.; Guetgemann, I.
    H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1 (2009), Hum. Pathol., 41, 181-189.
    View publication on PubMed
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Application

Application Comment Organism
diagnostics dimethylation of histone H3 at lysine 4 in combination with trimethylation of histone H3 at lysine 4 is associated with an activated transcriptional state. An increase of H3K4diMe in neoplastic tissues is predictive of clinical outcome. In particular, tumor recurrence occurs earlier in low-grade prostate carcinoma patients with low H3K4diMe, independently of other clinical and pathologic parameters. Similarly, in large cell and squamous cell carcinomas, low H3K4diMe expression correlates with short survival Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Homo sapiens lack of H3K4diMe is possibly due to complex epigenetic regulation involving Ash2 and LSD1 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cholangiocellular carcinoma cell
-
 Homo sapiens
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gastric cancer cell
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 Homo sapiens
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hepatobiliary carcinoma cell
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 Homo sapiens
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hepatoma cell
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 Homo sapiens
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additional information carcinoma tissue specific enzyme expression, overview Homo sapiens
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neuroendocrine carcinoma cell
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 Homo sapiens
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pancreatic ductal adenocarcinoma cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 lack of H3K4diMe is possibly due to complex epigenetic regulation involving Ash2 and LSD1 Homo sapiens [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?

Synonyms

Synonyms Comment Organism
demethylase LSD1
-
 Homo sapiens
LSD1
-
 Homo sapiens