Literature summary for 1.14.99.66 extracted from

Reddy, M.A.; Villeneuve, L.M.; Wang, M.; Lanting, L.; Natarajan, R.
Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice (2008), Circ. Res., 103, 615-623.

Search for more literature for 1.14.99.66

Protein Variants

Protein Variants	Comment	Organism
additional information	siRNA downregulation of LSD1 leads to significantly increased inflammatory gene expression and enhanced vascular smooth muscle cell-monocyte binding in nondiabetic mouse vascular smooth muscle cells, while overexpression in diabetic db/db mice vascular smooth muscle cells inhibits their enhanced inflammatory gene expression, phenotypes, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2	Mus musculus	-	[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	healthy and diabetic db/db mice with type 2 diabetes	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular smooth muscle cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2	-	Mus musculus	[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2	-	?

Synonyms

Synonyms	Comment	Organism
LSD1	-	Mus musculus
lysine-specific demethylase 1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	dysregulation of the enzyme action, in balance with the H3K4 methylation, may be a major cause for vascular inflammation and metabolic memory associated with diabetic complications, overview	Mus musculus
physiological function	LSD1 plays, together with H3K4 methylation, a functional role in inflammation in vascular smooth muscle cells, overview	Mus musculus

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Release 2023.1 (January 2023)