Literature summary for 1.14.99.48 extracted from

Reniere, M.L.; Skaar, E.P.
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem (2008), Mol. Microbiol., 69, 1304-1315.

Search for more literature for 1.14.99.48

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	Q7A649	-	-
Staphylococcus aureus	Q7A827	isoform IsdI	-
Staphylococcus aureus N315	Q7A649	-	-
Staphylococcus aureus N315	Q7A827	isoform IsdI	-

General Information

General Information	Comment	Organism
physiological function	isoforms IsdG and IsdI are both important for Staphylococcus aureus growth on haemin as a sole iron source and are necessary for full Staphylococcus aureus pathogenesis. Strains lacking IsdG, IsdI or both exhibit significantly impaired growth on hemin as a sole iron source when compared with wild-type. Inactivation of IsdG and IsdI in combination does not enhance the hemin utilization defect over that of either individual mutant strain. Overexpression of either IsdG or IsdI complements the loss of both enzymes, and expression of IsdG and IsdI is regulated by iron in a Fur-dependent manner and differentially regulated by iron and hemin	Staphylococcus aureus
physiological function	isoforms IsdG and IsdI are both important for Staphylococcus aureus growth on haemin as a sole iron source and are necessary for full Staphylococcus aureus pathogenesis. Strains lacking IsdG, IsdI or both exhibit significantly impaired growth on hemin as a sole iron source when compared with wild-type. Inactivation of IsdG and IsdI in combination does not enhance the hemin utilization defect over that of either individual mutant strain. Overexpression of either IsdG or IsdI complements the loss of both enzymes, and expression of IsdG and IsdI is regulated by iron in a Fur-dependent manner and differentially regulated by iron and hemin. Hemin-dependent upregulation of IsdG is occurring post-transcriptionally by enhancing its protein stability	Staphylococcus aureus

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Release 2023.1 (January 2023)