Cloned (Comment) | Organism |
---|---|
expressed in Huh-7.5.1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H242Q/H243Q | inactive | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + AH2 + O2 | Homo sapiens | - |
25-hydroxycholesterol + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q95992 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + AH2 + O2 | - |
Homo sapiens | 25-hydroxycholesterol + A + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CH25H | - |
Homo sapiens |
cholesterol-25-hydroxylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme restricts hepatitis C virus replication not only through its enzyme activity to produce 25-hydroxycholesterol but also by targeting the NS5A protein leading to the selective inhibition of NS5A dimer formation | Homo sapiens |