Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.99.38 extracted from

  • Ke, W.; Fang, L.; Jing, H.; Tao, R.; Wang, T.; Li, Y.; Long, S.; Wang, D.; Xiao, S.
    Cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication through enzyme activity-dependent and -independent mechanisms (2017), J. Virol., 91, e00827-17 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.38

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MARC-145 cells Sus scrofa

Protein Variants

Protein Variants Comment Organism
H242Q/H243Q inactive Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Sus scrofa
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage
-
 Sus scrofa
-
PK-15CD163 cell
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
 Sus scrofa 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CH25H
-
 Sus scrofa

Expression

Organism Comment Expression
Sus scrofa porcine reproductive and respiratory syndrome virus infection significantly downregulates the expression of the enzyme in cells down

General Information

General Information Comment Organism
physiological function cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication Sus scrofa