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Literature summary for 1.14.99.38 extracted from

  • Xiang, Y.; Tang, J.J.; Tao, W.; Cao, X.; Song, B.L.; Zhong, J.
    Identification of cholesterol 25-hydroxylase as a novel host restriction factor and a part of the primary innate immune responses against hepatitis C virus infection (2015), J. Virol., 89, 6805-6816 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Homo sapiens
-
25-hydroxycholesterol + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
-
Homo sapiens
-
Huh-7.5.1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
Homo sapiens 25-hydroxycholesterol + A + H2O
-
?

Synonyms

Synonyms Comment Organism
CH25H
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is not induced by interferons in human cells and knockdown of STAT-1 has no effect on the induction of the enzyme additional information
Homo sapiens the enzyme is upregulated upon poly(I:C) treatment or hepatitis C virus infection in hepatocytes up

General Information

General Information Comment Organism
physiological function the enzyme is a host restriction factor and part of the primary innate immune responses against hepatitis C virus infection. The enzyme inhibits hepatitis C virus infection by suppressing the maturation of sterol regulatory element-binding proteins, critical transcription factors for host lipid biosynthesis Homo sapiens