Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + AH2 + O2 | Homo sapiens | - |
25-hydroxycholesterol + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Huh-7 cell | - |
Homo sapiens | - |
Huh-7.5.1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + AH2 + O2 | - |
Homo sapiens | 25-hydroxycholesterol + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CH25H | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme expression is not induced by interferons in human cells and knockdown of STAT-1 has no effect on the induction of the enzyme | additional information |
Homo sapiens | the enzyme is upregulated upon poly(I:C) treatment or hepatitis C virus infection in hepatocytes | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is a host restriction factor and part of the primary innate immune responses against hepatitis C virus infection. The enzyme inhibits hepatitis C virus infection by suppressing the maturation of sterol regulatory element-binding proteins, critical transcription factors for host lipid biosynthesis | Homo sapiens |