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Literature summary for 1.14.99.38 extracted from

  • Lund, E.G.; Kerr, T.A.; Sakai, J.; Li, W.P.; Russell, D.W.
    cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism (1998), J. Biol. Chem., 273, 34316-34327.
    View publication on PubMed
Search for more literature for 1.14.99.38

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells, expression of cholesterol 25-hydroxylase in transfected cells reduces the biosynthesis of cholesterol from acetate and suppresses the cleavage of sterol regulatory element binding protein-1 and -2 Mus musculus
expression in COS cells, expression of cholesterol 25-hydroxylase in transfected cells reduces the biosynthesis of cholesterol from acetate and suppresses the cleavage of sterol regulatory element binding protein-1 and -2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane polytopic membrane protein Mus musculus 16020
-
membrane polytopic membrane protein Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe diiron cofactor Mus musculus
Fe diiron cofactor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + AH2 + O2 Mus musculus cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription 25-hydroxycholesterol + A + H2O
-
 ?
cholesterol + AH2 + O2 Homo sapiens cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription 25-hydroxycholesterol + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95992
-
-
Mus musculus Q9Z0F5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + AH2 + O2
-
 Mus musculus 25-hydroxycholesterol + A + H2O
-
 ?
cholesterol + AH2 + O2
-
 Homo sapiens 25-hydroxycholesterol + A + H2O
-
 ?
cholesterol + AH2 + O2 cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription Mus musculus 25-hydroxycholesterol + A + H2O
-
 ?
cholesterol + AH2 + O2 cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription Homo sapiens 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 25-hydroxylase
-
 Mus musculus
cholesterol 25-hydroxylase
-
 Homo sapiens