Literature summary for 1.14.99.29 extracted from

Han, Z.; Sakai, N.; Boettger, L.H.; Klinke, S.; Hauber, J.; Trautwein, A.X.; Hilgenfeld, R.
Crystal structure of the peroxo-diiron(III) intermediate of deoxyhypusine hydroxylase, an oxygenase involved in hypusination (2015), Structure, 23, 882-892 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with glycerol, hanging drop vapor diffusion method, using 30% polyethylene glycol 6000 (w/v), 400 mM guanidinium hydrochloride, 100 mM Bis-Tris propane (pH 7.2-7.4).	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	non-heme diiron enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[eIF5A]-deoxyhypusine + AH2 + O2	Homo sapiens	-	[eIF5A]-hypusine + A + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BU89	-	-

Purification (Commentary)

Purification (Comment)	Organism
GST column chromatography and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[eIF5A]-deoxyhypusine + AH2 + O2	-	Homo sapiens	[eIF5A]-hypusine + A + H2O	-	?

Synonyms

Synonyms	Comment	Organism
deoxyhypusine hydroxylase	-	Homo sapiens
DOHH	-	Homo sapiens

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Release 2023.1 (January 2023)