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Literature summary for 1.14.99.29 extracted from

  • Epis, M.R.; Giles, K.M.; Kalinowski, F.C.; Barker, A.; Cohen, R.J.; Leedman, P.J.
    Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells (2012), J. Biol. Chem., 287, 35251-35259.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.29

Cloned(Commentary)

Cloned (Comment) Organism
gene dohh, quantitative expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
mimosine synergistic growth inhibition with the combination of miR-331-3p and miR-642-5p and mimosine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2 Homo sapiens
-
 [eIF5A]-hypusine + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BU89 gene dohh, substrain PEXT-1
-

Source Tissue

Source Tissue Comment Organism Textmining
22Rv-1 cell
-
 Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
LNCAP-C4-2B cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
prostate gland epithelium
-
 Homo sapiens
-
RWPE-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A]-deoxyhypusine + AH2 + O2
-
 Homo sapiens [eIF5A]-hypusine + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
deoxyhypusine hydroxylase
-
 Homo sapiens
DOHH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens transient overexpression of micro-RNA miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation down

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the activation of eukaryotic translation initiation factor, eIF5A, a protein essential for cell growth. Expression of DOHH is regulated by micro-RNAs miR-331-3p and miR-642-5p in prostate cancer cells, overview. Transient overexpression of miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation Homo sapiens