Application | Comment | Organism |
---|---|---|
medicine | the results support the concept that drugs targeting DOHH should be tested clinically for HIV-1 inhibition and could be developed as antiretrovirals | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ciclopirox | CPX, topical fungicide | Homo sapiens | |
deferiprone | DEF, systemic medicinal iron chelator | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PBMC cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deoxyhypusine hydroxylase | - |
Homo sapiens |
DOHH | - |
Homo sapiens |