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Literature summary for 1.14.99.29 extracted from

  • Kim, Y.S.; Kang, K.R.; Wolff, E.C.; Bell, J.K.; McPhie, P.; Park, M.H.
    Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis (2006), J. Biol. Chem., 281, 13217-13225.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
E208A little reduction in iron content of enzyme, complete loss of activity Homo sapiens
E241A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens
E57A little reduction in iron content of enzyme, complete loss of activity Homo sapiens
E90A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens
H207A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens
H240A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens
H56A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens
H89A severe reduction in iron content of enzyme, complete loss of activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Iron 2 mol of iron per mol of enzyme Homo sapiens
additional information iron cannot be replaced by Cd2+, Co2+, Cr2+, Cu2+, Mg2+, Mn2+, Ni2+, Zn2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
[eIF5A]-deoxyhypusine + reduced acceptor + O2 = [eIF5A]-hypusine + acceptor + H2O binuclear iron mediated reaction mechanism Homo sapiens
a

Renatured (Commentary)

Renatured (Comment) Organism
activity of metal-free apoenzyme can be restored by addition of Fe2+, but not by Cd2+, Co2+, Cr2+, Cu2+, Mg2+, Mn2+, Ni2+, Zn2+ Homo sapiens

Synonyms

Synonyms Comment Organism
DOHH
-
 Homo sapiens