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Literature summary for 1.14.99.29 extracted from

  • Abbruzzese, A.; Liguori, V.; Park, M.H.
    Deoxyhypusine hydroxylase (1988), Adv. Exp. Med. Biol., 250, 459-466.
    View publication on PubMed
Search for more literature for 1.14.99.29

Activating Compound

Activating Compound Comment Organism Structure
sulfhydryl compound
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline complete inhibition at 0.01 mM Rattus norvegicus
FeSO4 13% of initial activity at 0.005 mM Rattus norvegicus
additional information partial reconstitution of 0.01 mM 1,10-phenanthroline inhibited activity with Co(C2H3O2)2 at 0.03 mM or FeSO4 at 0.005 mM Rattus norvegicus
Picolinic acid
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000052
-
 deoxyhypusine
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information distribution in mammals Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 corresponds to 2.8 pmol/min/mg for partially purified enzyme Rattus norvegicus
416
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Rattus norvegicus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5 in 20 mM Tris buffer Rattus norvegicus