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Literature summary for 1.14.99.29 extracted from

  • Hanauske-Abel, H.M.; Park, M.H.; Hanauske, A.R.; Popowicz, A.M.; Lalande, M.; Folk, J.E.
    Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation (1994), Biochim. Biophys. Acta, 1221, 115-124.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-(2-hydroxy-5-methylphenyl)-1,3-thiazole-4-carboxylic acid inhibition in vitro and in cells Cricetulus griseus
2-(2-hydroxy-5-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid inhibition in vitro and in cells Cricetulus griseus
2-(2-hydroxy-5-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid inhibition in vitro and in cells Homo sapiens
mimosine reversible inhibition Cricetulus griseus
mimosine S-isomer, complete inhibition at 0.2 mM in LAZ463 cells Homo sapiens
additional information no inhibition by S-isomers of kojic acid, 3-pyridylalanine, 4-pyridylalanine at 0.3 mM in vitro and at 0.2 mM in cells, no inhibition by 2-(2-aminophenyl)-1,3-thiazole-4-carboxylic acid at 0.4 mM in cells Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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-
-
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Cricetulus griseus N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?
N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Homo sapiens N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?