Application | Comment | Organism |
---|---|---|
medicine | enzyme catalyzes the production of 9alpha-hydroxy-4-androstene-3,17-dione, an important intermediate for the semi-synthesis of potent anti-inflammatory drugs such as 9alpha-fluorocorticoids from 4-androstene-3,17-dione | Corynebacterium sp. |
synthesis | steroid 9alpha-hydroxylase in company with delta-dehydrogenase is used in industrial processes | Corynebacterium sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | Corynebacterium sp. | key enzyme system in steroid nucleus degradation in company with delta-dehydrogenase | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium sp. | - |
synonym Nocardia restrictus, ATCC 14887 (MCI 1354) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | - |
Corynebacterium sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
4,9(11)-pregnadiene-3,20-dione + NADH + O2 | key enzyme system in steroid nucleus degradation in company with delta-dehydrogenase | Corynebacterium sp. | 9,11alpha-epoxypregn-4-ene-3,20-dione + NAD+ + H2O | - |
? | |
9(11)-dehydro-17alpha-methyl-testosterone + NADH + O2 | - |
Corynebacterium sp. | 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-4-androstene-3-one + 9alpha,11alpha-oxido-17beta-hydroxy-17alpha-methyl-1,4-androstadiene-3-one + NAD+ + H2O | - |
? |