Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.99.1 extracted from

  • Brant, K.A.; Leikauf, G.D.
    Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells (2012), Mol. Carcinog., 53, 192-200.
    View publication on PubMed
Search for more literature for 1.14.99.1

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
NS-398 inhibits PTGS2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35354
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelium
-
 Homo sapiens
-
additional information quantitative real-time RT-PCR enzyme expression analysis, overview Homo sapiens
-
NCI-H292 cell
-
 Homo sapiens
-
non-small cell lung cancer cell increased expression of PTGS2 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Cox2
-
 Homo sapiens
cyclooxygenase
-
 Homo sapiens
prostaglandin G/H synthase
-
 Homo sapiens
prostaglandin-endoperoxide synthase 2
-
 Homo sapiens
PTGS2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens when NCI-H292 cells are transfected with E2F1 siRNA, PTGS2 expression is attenuated down

General Information

General Information Comment Organism
physiological function PTGS2 plays a pivotal role in inflammation, tissue damage, and tumorigenesis. Differential regulation of PCSKs by PTGS2 with a pivotal role for E2F1, implication of PTGS2-derived PGE2 as a determining factor in the regulation of PCSK activity Homo sapiens