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Literature summary for 1.14.99.1 extracted from

  • Joseph, T.; Zalenskaya, I.A.; Sawyer, L.C.; Chandra, N.; Doncel, G.F.
    Seminal plasma induces prostaglandin-endoperoxide synthase (PTGS) 2 expression in immortalized human vaginal cells: involvement of semen prostaglandin E2 in PTGS2 upregulation (2013), Biol. Reprod., 88, 13.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
quantitative RT-PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35354
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Source Tissue

Source Tissue Comment Organism Textmining
cervical mucosa
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 Homo sapiens
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cervicovaginal cell seminal plasma induces and potentiates the expression of PTGS2 in cervicovaginal cells and tissues Homo sapiens
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additional information quantitative RT-PCR enzyme expression and immunohistochemic analysis, overview Homo sapiens
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VK-2/E6E7 cell vaginal cell line, expression of prostaglandin-endoperoxide synthase 2, i.e. cyclooxygenase 2, in human vaginal cells in response to toll-like receptor ligands and other proinflammatory stimuli, such vaginal mucosal irritant nonoxynol-9, in a synergistic manner Homo sapiens
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Synonyms

Synonyms Comment Organism
COX-2
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 Homo sapiens
cyclooxygenase 2
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 Homo sapiens
prostaglandin-endoperoxide synthase 2
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 Homo sapiens
PTGS 2
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens seminal plasma induces prostaglandin-endoperoxide synthase 2 expression in immortalized human vaginal cells, involvement of semen prostaglandin E2 in PTGS2 upregulation. Expression of prostaglandin-endoperoxide synthase 2, i.e. cyclooxygenase 2, in human vaginal cells in response to toll-like receptor ligands and other proinflammatory stimuli. Seminal prostaglandin-E2 is one of the major factors in PTGS2 induction up

General Information

General Information Comment Organism
additional information seminal plasma-induced PTGS2 expression is mediated by intracellular signaling pathways involving MAPKs and NF-kappaB. Depending on cell type and stimulus, different intracellular signaling pathways are involved in inflammation and PTGS2 expression Homo sapiens