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Literature summary for 1.14.99.1 extracted from
- Inhibition of cyclooxygenase activity of prostaglandin-H-synthase by excess substrate (molecular oxygen) (2010), Biochemistry (Moscow), 75, 1368-1373.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| O2 | the cyclooxygenase reaction is inhibited by an excess of dissolved oxygen, 0.5 mM O2 causes twofold decrease in the initial rate and maximal yield | Ovis aries |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | the cyclooxygenase reaction shows Michaelis-Menten kinetics over a wide range of oxygen concentrations in the absence of electron donor. Kinetics analysis, overview | Ovis aries |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Ovis aries | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + 2 O2 | Ovis aries | - |
prostaglandin G2 | - |
? | |
| prostaglandin G2 + AH2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
male | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| vesicular gland | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + 2 O2 | - |
Ovis aries | prostaglandin G2 | - |
? | |
| additional information | maximal values of the initial reaction rate and yield of the product are attained at oxygen concentration 0.05 mM | Ovis aries | ? | - |
? | |
| prostaglandin G2 + AH2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclooxygenase | - |
Ovis aries |
| PGHS | - |
Ovis aries |
| prostaglandin-H-synthase | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Ovis aries |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the committed step in prostaglandin biosynthesis | Ovis aries |
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