Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-linolenic acid | - |
Ovis aries | |
DCM-extract of Angelicae dahuricae radix | 0.1% inhibition of PGHS-1; 38.8% inhibition of PGHS-2 | Ovis aries | |
DCM-extract of Angelicae sinsesis radix | 55.8% inhibition of PGHS-2; 75.0% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Atractylodis lanceae rhizoma | 46.9% inhibition of PGHS-1; 50.3% inhibition of PGHS-2 | Ovis aries | |
DCM-extract of Atractylodis macrocephalae rhizoma | 47.0% inhibition of PGHS-2; 58.6% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Cinnamomi ramulus | 48.4% inhibition of PGHS-2; 73.5% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Houttuyniae herba | 40.9% inhibition of PGHS-2; 46.8% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Notopterygii rhizoma seu radix | -2.1% inhibition of PGHS-2; 42.6% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Piperis sarmentosi herba | 10.1% inhibition of PGHS-2; 47.2% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Platycodi radix | 70.1% inhibition of PGHS-2; 77.8% inhibition of PGHS-1 | Ovis aries | |
DCM-extract of Zanthoxyli pericarpium | 18.3% inhibition of PGHS-1; 31.3% inhibition of PGHS-2 | Ovis aries | |
DCM-extract of Zingiberis rhizoma | 41.3% inhibition of PGHS-2; 52.9% inhibition of PGHS-1 | Ovis aries | |
indomethacin | - |
Ovis aries | |
linoleic acid | - |
Ovis aries | |
n-hexane extract of Angelicae dahuricae radix | 42.4% inhibition of PGHS-2; 52.5% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Angelicae sinsesis radix | 61.5% inhibition of PGHS-2; 73.0% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Atractylodis lanceae rhizoma | 67.4% inhibition of PGHS-1; 68.3% inhibition of PGHS-2 | Ovis aries | |
n-hexane extract of Atractylodis macrocephalae rhizoma | 46.1% inhibition of PGHS-1; 48.9% inhibition of PGHS-2 | Ovis aries | |
n-hexane extract of Cinnamomi ramulus | 23.6% inhibition of PGHS-2; 46.6% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Houttuyniae herba | 43.4% inhibition of PGHS-2; 50.3% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Notopterygii rhizoma seu radix | 64.9% inhibition of PGHS-2; 69.6% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Piperis sarmentosi herba | 52.4% inhibition of PGHS-1; 65.0% inhibition of PGHS-2 | Ovis aries | |
n-hexane extract of Platycodi radix | 48.7% inhibition of PGHS-1; 55.1% inhibition of PGHS-2 | Ovis aries | |
n-hexane extract of Zanthoxyli pericarpium | 24.9% inhibition of PGHS-2; 48.5% inhibition of PGHS-1 | Ovis aries | |
n-hexane extract of Zingiberis rhizoma | 77.5% inhibition of PGHS-2; 83.4% inhibition of PGHS-1 | Ovis aries | |
NS-398 | - |
Ovis aries | |
oleic acid | - |
Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | P05979 | PGHS-1 | - |
Ovis aries | P79208 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seminal vesicle | PGHS-1 | Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGHS-1 | - |
Ovis aries |
PGHS-2 | - |
Ovis aries |
prostaglandin-H-synthase 1 | - |
Ovis aries |
prostaglandin-H-synthase 2 | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
activity assay at room temperature | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
activity assay | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Hematin | - |
Ovis aries | |
additional information | epinephrine-hydrogentartrate can serve as cofactor | Ovis aries | |
additional information | epinephrine-hydrogentartrate can servve as cofactor | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
inhibition of PGHS-2 | Ovis aries | indomethacin | |
0.0009 | - |
inhibition of PGHS-1 | Ovis aries | indomethacin | |
0.0026 | - |
inhibition of PGHS-2 | Ovis aries | linoleic acid | |
0.0026 | - |
inhibition of PGHS-2 | Ovis aries | NS-398 | |
0.003 | - |
inhibition of PGHS-2 | Ovis aries | alpha-linolenic acid | |
0.0198 | - |
inhibition of PGHS-1 | Ovis aries | linoleic acid | |
0.0212 | - |
inhibition of PGHS-1 | Ovis aries | alpha-linolenic acid | |
0.0507 | - |
inhibition of PGHS-1 | Ovis aries | NS-398 | |
0.1226 | - |
inhibition of PGHS-2 | Ovis aries | oleic acid | |
0.1245 | - |
inhibition of PGHS-1 | Ovis aries | oleic acid |