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Literature summary for 1.14.99.1 extracted from

  • Trostchansky, A.; Odonnell, V.B.; Goodwin, D.C.; Landino, L.M.; Marnett, L.J.; Radi, R.; Rubbo, H.
    Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation (2007), Free Radic. Biol. Med., 42, 1029-1038.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bicarbonate bicarbonate enhances peroxynitrite-mediated peroxidase inactivation Ovis aries
indomethacin
-
Ovis aries
peroxynitrite
-
Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + AH2 + O2 Ovis aries
-
prostaglandin H2 + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
seminal vesicle
-
Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + AH2 + O2
-
Ovis aries prostaglandin H2 + A + H2O
-
?

Synonyms

Synonyms Comment Organism
PGHS-1
-
Ovis aries
prostaglandin endoperoxide H synthase-1
-
Ovis aries

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
activity assay, determination of cyclooxygenase and peroxidase activity Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
activity assay, determination of cyclooxygenase and peroxidase activity Ovis aries

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0186
-
cyclooxygenase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed Ovis aries peroxynitrite
0.0222
-
peroxidase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed Ovis aries peroxynitrite
0.03
-
cyclooxygenase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid Ovis aries peroxynitrite
0.0388
-
peroxidase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid Ovis aries peroxynitrite