Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bicarbonate | bicarbonate enhances peroxynitrite-mediated peroxidase inactivation | Ovis aries | |
indomethacin | - |
Ovis aries | |
peroxynitrite | - |
Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Ovis aries | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seminal vesicle | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Ovis aries | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGHS-1 | - |
Ovis aries |
prostaglandin endoperoxide H synthase-1 | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
activity assay, determination of cyclooxygenase and peroxidase activity | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay, determination of cyclooxygenase and peroxidase activity | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0186 | - |
cyclooxygenase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed | Ovis aries | peroxynitrite | |
0.0222 | - |
peroxidase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed | Ovis aries | peroxynitrite | |
0.03 | - |
cyclooxygenase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid | Ovis aries | peroxynitrite | |
0.0388 | - |
peroxidase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid | Ovis aries | peroxynitrite |