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Literature summary for 1.14.99.1 extracted from

  • Patrignani, P.; Panara, M.R.; Sciulli, M.G.; Santini, G.; Renda, G.; Patrono, C.
    Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs (1997), J. Physiol. Pharmacol., 48, 623-631.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
diclofenac isozyme 1, 50% inhibition at 0.0003 mM, isozyme 2, 50% inhibition at 18 nM Homo sapiens
flurbiprofen isozyme 1, 50% inhibition at 0.0009 mM, isozyme 2, 50% inhibition at 0.0009 mM Homo sapiens
Ibuprofen isozyme 1, 50% inhibition at 0.009 mM, isozyme 2, 50% inhibition at 0.018 mM Homo sapiens
indomethacin isozyme 1 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.0003 mM Homo sapiens
Ketoprofen isozyme 1, 50% inhibition at 0.011 mM, isozyme 2, 50% inhibition at 0.018 mM Homo sapiens
L-745 isozyme 1, 50% inhibition at 0.369 mM, isozyme 2, 50% inhibition at 0.002 mM Homo sapiens
meloxicam isozyme 1, 50% inhibition at 0.005 mM, isozyme 2, 50% inhibition at 0.0004 mM Homo sapiens
N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide isozyme 1, 50% inhibition at 0.017 mM, isozyme 2, 50% inhibition at 0.0001 mM Homo sapiens
nimesulide isozyme 1, 50% inhibition at 0.009 mM, isozyme 2, 50% inhibition at 0.0005 mM Homo sapiens
piroxicam isozyme 1, 50% inhibition at 0.009-0.024 mM, isozyme 2, 50% inhibition at 0.070-0.240 mM Homo sapiens
SC58125 isozyme 1, 50% inhibition at 0.039 mM, isozyme 2, 50% inhibition at 0.0003 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
monocyte isozyme 2 Homo sapiens
-
platelet isozyme 1 Homo sapiens
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