Literature summary for 1.14.20.3 extracted from

Stapon, A.; Li, R.; Townsend, C.A.
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline (2003), J. Am. Chem. Soc., 125, 8486-8493.

Search for more literature for 1.14.20.3

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Pectobacterium carotovorum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(3S,5S)-carbapen-2-am-3-carboxylate + 2-oxoglutarate + O2	Pectobacterium carotovorum	the enzyme is involved in the biosynthesis of (5R)-carbapen-2-em-3-carboxylic acid the simplest structurally among the naturally occurring carbapenem beta-lactam antibiotics	(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Pectobacterium carotovorum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(3S,5S)-carbapen-2-am-3-carboxylate + 2-oxoglutarate + O2	-	Pectobacterium carotovorum	(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O	-	?
(3S,5S)-carbapen-2-am-3-carboxylate + 2-oxoglutarate + O2	the enzyme is involved in the biosynthesis of (5R)-carbapen-2-em-3-carboxylic acid the simplest structurally among the naturally occurring carbapenem beta-lactam antibiotics	Pectobacterium carotovorum	(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CarC	-	Pectobacterium carotovorum

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Release 2023.1 (January 2023)