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Literature summary for 1.14.20.3 extracted from

  • Sleeman, M.C.; Smith, P.; Kellam, B.; Chhabra, S.R.; Bycroft, B.W.; Schofield, C.J.
    Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC) (2004), Chembiochem, 5, 879-882.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbate activity with the natural substrate (3S,5S)-carbapenam-3-carboxylate in absence of ascorbate is 2% compared to the activity in presence of ascorbate. Ascorbate does not stimulate turnover of the (3S,5R)- or (3R,5R)-stereoisomers Pectobacterium carotovorum

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Pectobacterium carotovorum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 Pectobacterium carotovorum
-
(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pectobacterium carotovorum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R,5R)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 activity in presence of ascorbate is 22% compared to the activity with the natural substrate (3S,5S)-carbapenam-3-carboxylate, activity in absence of ascorbate is 86% compared to the activity with the natural substrate (3S,5S)-carbapenam-3-carboxylate in presence of ascorbate Pectobacterium carotovorum (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?
(3R,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 activity in presence of ascorbate is less than 2% compared to the activity with the natural substrate (3S,5S)-carbapenam, activity in absence of ascorbate is 40% compared to the activity with the natural substrate (3S,5S)-carbapenam in presence of ascorbate Pectobacterium carotovorum (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?
(3S,5R)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 activity in presence of ascorbate is 76% compared to the activity with the natural substrate (3S,5S)-carbapenam-3-carboxylate, activity in absence of ascorbate is 7% compared to the activity with the natural substrate (3S,5S)-carbapenam-3-carboxylate in presence of ascorbate Pectobacterium carotovorum (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2
-
Pectobacterium carotovorum (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 natural substrate. Activity with in absence of ascorbate is 2% compared to the activity in presence of ascorbate Pectobacterium carotovorum (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
-
?

Synonyms

Synonyms Comment Organism
CarC
-
Pectobacterium carotovorum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
assay at Pectobacterium carotovorum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Pectobacterium carotovorum