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Literature summary for 1.14.20.11 extracted from

  • Hillwig, M.; Zhu, Q.; Liu, X.
    Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua (2014), ACS Chem. Biol., 9, 372-377 .
    View publication on PubMed
Search for more literature for 1.14.20.11

Cloned(Commentary)

Cloned (Comment) Organism
exprerssion in Escherichia coli Fischerella ambigua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 Fischerella ambigua
-
 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
-
 ?
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 Fischerella ambigua UTEX 1903
-
 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Fischerella ambigua V5TD18
-
-
Fischerella ambigua UTEX 1903 V5TD18
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2
-
 Fischerella ambigua 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
-
 ?
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2
-
 Fischerella ambigua UTEX 1903 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
ambI3
-
 Fischerella ambigua
famH3
-
 Fischerella ambigua

General Information

General Information Comment Organism
physiological function presence of isonitrile synthase AmbI1 and AmbI3 alone are sufficient to generate 3-[(Z)-2-isocyanoethenyl]-1H-indole from L-Trp and ribulose 5-phosphate Fischerella ambigua