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Literature summary for 1.14.19.9 extracted from

  • Fraebel, S.; Krischke, M.; Staniek, A.; Warzecha, H.
    Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes (2016), Biotechnol. J., 11, 1586-1594 .
    View publication on PubMed
Search for more literature for 1.14.19.9

Cloned(Commentary)

Cloned (Comment) Organism
gene rebH, functional recombinant expression of Yfp-tagged enzyme in Nicotianan benthamiana leaf cytosol via Agrobacterium tumefaciens tranfection method under control of the CaMV 35S promoter leading to formation of 7-chlorotryptophan, coexpression with gene rebF from Lechevalieria aerocolonigenes, different genetic constructs, overview. Coexpression and concerted activity of tryptophan 6-halogenase Stth, EC 1.14.19.59, and RebH lead to formation of 6,7-halotryptophan Lentzea aerocolonigenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-chloro-L-tryptophan + FADH2 + chloride + O2 + H+ Lentzea aerocolonigenes
-
 6,7-dichloro-L-tryptophan + FAD + 2 H2O
-
 ?
L-tryptophan + FADH2 + chloride + O2 + H+ Lentzea aerocolonigenes
-
 7-chloro-L-tryptophan + FAD + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Lentzea aerocolonigenes Q8KHZ8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-chloro-L-tryptophan + FADH2 + chloride + O2 + H+
-
 Lentzea aerocolonigenes 6,7-dichloro-L-tryptophan + FAD + 2 H2O
-
 ?
L-tryptophan + FADH2 + chloride + O2 + H+
-
 Lentzea aerocolonigenes 7-chloro-L-tryptophan + FAD + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
RebH
-
 Lentzea aerocolonigenes

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Lentzea aerocolonigenes