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Literature summary for 1.14.19.9 extracted from
- Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor (2011), J. Am. Chem. Soc., 133, 19346-19349.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| mutant enzyme Y455W is expressed in Catharanthus roseus | Lentzea aerocolonigenes |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y455W | the mutant preferentially uses tryptamine as substrate | Lentzea aerocolonigenes |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tryptophan + FADH2 + Cl- + O2 + H+ | Lentzea aerocolonigenes | - |
7-chloro-L-tryptophan + FAD + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lentzea aerocolonigenes | Q8KHZ8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tryptamine + FADH2 + Cl- + O2 + H+ | - |
Lentzea aerocolonigenes | 7-chloro-L-tryptamine + FAD + H2O | - |
? | |
| tryptophan + FADH2 + Cl- + O2 + H+ | - |
Lentzea aerocolonigenes | 7-chloro-L-tryptophan + FAD + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RebH | - |
Lentzea aerocolonigenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FADH2 | - |
Lentzea aerocolonigenes | |
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Release 2023.1 (January 2023)
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