Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.19.9 extracted from

  • Hölzer, M.; Burd, W.; Reißig, H.U.; van pee, K.-H.
    Substrate specificity and regioselectivity of tryptophan 7-halogenase from Pseudomonas fluorescens BL915 (2001), Adv. Synth. Catal., 343, 591-595.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tryptophan + FADH2 + Cl- + O2 + H+ Pseudomonas fluorescens chlorination of its natural substrate tryptophan exclusively at the 7-position, a position at which direct chemical chlorination is not possible 7-chloro-tryptophan + FAD + H2O
-
?
tryptophan + FADH2 + Cl- + O2 + H+ Pseudomonas fluorescens BL915 chlorination of its natural substrate tryptophan exclusively at the 7-position, a position at which direct chemical chlorination is not possible 7-chloro-tryptophan + FAD + H2O
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens Q9RPG3 BL915
-
Pseudomonas fluorescens BL915 Q9RPG3 BL915
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Trp 7-hal can accept a number of different tryptophan, indole, and phenylpyrrole derivatives (e.g. 3-(2'-aminophenyl)pyrrole or monodechloroaminopyrrolnitrin), but only tryptophan is regioselectively chlorinated in the 7-position of the indole ring. With all the other compounds, the reaction proceeds with a relaxed regioselectivity Pseudomonas fluorescens ?
-
?
additional information Trp 7-hal can accept a number of different tryptophan, indole, and phenylpyrrole derivatives (e.g. 3-(2'-aminophenyl)pyrrole or monodechloroaminopyrrolnitrin), but only tryptophan is regioselectively chlorinated in the 7-position of the indole ring. With all the other compounds, the reaction proceeds with a relaxed regioselectivity Pseudomonas fluorescens BL915 ?
-
?
tryptophan + FADH2 + Cl- + O2 + H+
-
Pseudomonas fluorescens 7-chloro-tryptophan + FAD + H2O
-
?
tryptophan + FADH2 + Cl- + O2 + H+ chlorination of its natural substrate tryptophan exclusively at the 7-position, a position at which direct chemical chlorination is not possible Pseudomonas fluorescens 7-chloro-tryptophan + FAD + H2O
-
?
tryptophan + FADH2 + Cl- + O2 + H+
-
Pseudomonas fluorescens BL915 7-chloro-tryptophan + FAD + H2O
-
?
tryptophan + FADH2 + Cl- + O2 + H+ chlorination of its natural substrate tryptophan exclusively at the 7-position, a position at which direct chemical chlorination is not possible Pseudomonas fluorescens BL915 7-chloro-tryptophan + FAD + H2O
-
?

Synonyms

Synonyms Comment Organism
Trp 7-hal
-
Pseudomonas fluorescens