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Literature summary for 1.14.19.9 extracted from
- Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination (2005), Science, 309, 2216-2219.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| protein without ligands and in presence of tryptophan and 7-chlorotryptophan | Pseudomonas fluorescens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas fluorescens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-L-tryptophan + FAD + 2 H2O | FADH2 reacts with O2 to make peroxyflavin, which is decomposed by Cl-. the resulting HOCl is guided through the tunnel to tryptophan, where it is activated to participate in electrophilic aromatic substitution | Pseudomonas fluorescens |
aSynonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PrnA | - |
Pseudomonas fluorescens |
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Release 2023.1 (January 2023)
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