Cloned (Comment) | Organism |
---|---|
heterologously expressed in Saccharomyces cerevisiae | Chelidonium majus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 | Chelidonium majus | the enzyme is involved in biosynthesis of stylopine | (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chelidonium majus | A0A240FWB4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | expression is very similar in both roots and leaves, although the alkaloid accumulation patterns in these organs are quite different | Chelidonium majus | - |
root | expression is very similar in both roots and leaves, although the alkaloid accumulation patterns in these organs are quite different | Chelidonium majus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme is involved in biosynthesis of stylopine | Chelidonium majus | (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? | |
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 | high substrate specificity. The only alternative substrate identified is scoulerine, which is converted by stylopine synthase to yield minor amounts of nandinine | Chelidonium majus | (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? | |
(S)-scoulerine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Chelidonium majus | nandinine + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
stylopine synthase | - |
Chelidonium majus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH-hemoprotein reductase | - |
Chelidonium majus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in biosynthesis of stylopine | Chelidonium majus |