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Literature summary for 1.14.19.62 extracted from

  • Guirimand, G.; Guihur, A.; Ginis, O.; Poutrain, P.; Hericourt, F.; Oudin, A.; Lanoue, A.; St-Pierre, B.; Burlat, V.; Courdavault, V.
    The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites (2011), FEBS J., 278, 749-763.
    View publication on PubMed
Search for more literature for 1.14.19.62

Cloned(Commentary)

Cloned (Comment) Organism
expression of SLS-GFP fusion protein in Catharanthus roseus cells show localization to the endoplasmic reticulum membranes Catharanthus roseus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the enzyme is anchored to the endoplasmic reticulum via a N-teminal helix, thus allowing the production of secologanin on the cytosolic side of the endoplasmic reticulum membrane Catharanthus roseus 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
loganin + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis epidermis-specific expression of SLS Catharanthus roseus
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leaf
-
 Catharanthus roseus
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additional information RT-PCR tissue expression analysis, overview Catharanthus roseus
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seedling
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
loganin + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP71A1
-
 Catharanthus roseus
cytochrome P450 secologanin synthase
-
 Catharanthus roseus
SLS
-
 Catharanthus roseus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 CYP71A1 Catharanthus roseus

General Information

General Information Comment Organism
malfunction mutant DELTAthSLS fusion protein forms punctuated aggregates in the cytosol in close vicinity with plastids Catharanthus roseus
metabolism the enzyme catalyzes the last step of the monoterpene secoiridoid pathway Catharanthus roseus
additional information the enzyme is anchored to the endoplasmic reticulum via a N-teminal helix, thus allowing the production of secologanin on the cytosolic side of the endoplasmic reticulum membrane Catharanthus roseus