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Literature summary for 1.14.19.62 extracted from

  • Yamamoto, H.; Katano, N.; Ooi, A.; Inoue, K.
    Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450 (2000), Phytochemistry, 53, 7-12.
    View publication on PubMed
Search for more literature for 1.14.19.62

Inhibitors

Inhibitors Comment Organism Structure
Ancymidol complete inhibition Lonicera japonica
carbon monoxide inhibition by CO and O2 in the ratio 9 to 1 in the dark, can be reversed by illumination with white light Lonicera japonica
cytochrome c partial inhibition Lonicera japonica
Metyrapone partial inhibition Lonicera japonica
miconazole partial inhibition Lonicera japonica

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome membrane-associated enzyme Lonicera japonica
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
loganin + [reduced NADPH-hemoprotein reductase] + O2 Lonicera japonica
-
 secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Lonicera japonica
-
-
-

Reaction

Reaction Comment Organism Reaction ID
loganin + [reduced NADPH-hemoprotein reductase] + O2 = secologanin + [oxidized NADPH-hemoprotein reductase] + 2 H2O enzyme belongs to the group of cytochrome P450 monooxygenases Lonicera japonica
a

Source Tissue

Source Tissue Comment Organism Textmining
cell suspension culture 10-days-old cultured cells Lonicera japonica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
loganin + [reduced NADPH-hemoprotein reductase] + O2
-
 Lonicera japonica secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
loganin + [reduced NADPH-hemoprotein reductase] + O2 requires molecular oxygen for oxidative cleavage of the carbon-carbon bond Lonicera japonica secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information no substrates: loganic acid, 10-hydroxyloganin, 7-epiloganin, 7-dehydrologanin, 7-dehydrologanic acid, 8-epiloganin, verbenalin Lonicera japonica ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 enzyme assay Lonicera japonica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Lonicera japonica